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Luke Edwards
Luke Edwards

Where To Buy Promeris For Dogs [BEST]



Amitraz can be dangerous when combined with antidepressants, such as Prozac (fluoxetine), or with other MAOI inhibitors, such as Anipryl (l-deprenyl, selegiline). DL-Phenylalanine (DLPA), used to treat chronic pain in dogs, should also be avoided when using MAOIs, such as amitraz. Cats are at risk if they come into contact with topical products, and even owners who are taking MAOIs themselves may run into problems using these products on their dogs.




where to buy promeris for dogs



In late March, the journal Veterinary Dermatology published an article from researchers at North Carolina State University who found that ProMeris has the potential to trigger a variant of pemphigus foliaceus in dogs.


The article reports on 22 dogs that developed PF-like cutaneous drug reactions at the site of ProMeris application. Eight dogs developed lesions only at the application site, whereas the other 14 dogs developed skin lesions at the application site as well as at other noncontiguous sites.


Promeris Duo (PD) is a novel topical flea and tick preventative for dogs, which is also licensed for treatment of canine demodicosis. In this article, we present 22 dogs that all developed pemphigus foliaceus (PF)-like cutaneous drug reactions at the site of PD application. In eight dogs, the lesions were restricted to the application site (localized group). Signs of systemic illness were reported in three dogs, and four required immunosuppressive treatment. Direct immunofluorescence for IgG was positive in four dogs, although circulating antikeratinocyte IgG could not be detected in any tested sera. Complete remission was achieved in all dogs, with one patient still remaining on treatment. Fourteen dogs developed skin lesions at the application site as well as other noncontiguous areas (distant group). Systemic signs were reported in 11 dogs, and immunosuppression was required in 10 cases. Direct and indirect immunofluorescence tests were positive for antikeratinocyte autoantibodies in 10 of 13 and six of 10 patients with distant disease, respectively. Complete remission was achieved in 10 of 13 dogs with distant disease; one-third are still on treatment. Histological changes were similar to canine PF. Desmosomal architectural changes, assessed by desmoglein-1 immunostaining, were also similar to those of dogs with spontaneous autoimmune PF. Apoptosis did not appear to contribute to lesion formation, in either autoimmune or PD-associated PF. In conclusion, PD has the potential of triggering a variant of PF that resembles spontaneously occurring autoimmune PF at clinical, morphological, immunological and treatment outcome levels.


For the treatment and prevention of infestations by fleas (Ctenocephalides canis and C. felis), and ticks (Ixodes ricinus, Ixodes hexagonus, Rhipicephalus sanguineus, Dermacentor reticulatus and Dermacentor variabilis), and treatment of demodicosis (caused by Demodex spp.) and lice (Trichodectes canis) in dogs.


Canine demodicosis can be divided into two clinical manifestations. The localized form appears as small patches of alopecia and mild erythema in young dogs. It generally regresses spontaneously without treatment. The generalized form of demodicosis is more severe and can even be fatal. It may develop from the localized condition or occur in older animals, especially those undergoing severe stress or with underlying diseases. The definition of localized versus generalized demodicosis has been a matter of debate. A recent committee of experts considered demodicosis as localized if there are no more than four lesions with a diameter of up to 2.5 cm in width [5, 9]. Canine generalized demodicosis is frequently seen in practice [13] and is characterized by five or more affected areas or by lesions covering an entire region of the body, and/or pododemodicosis involving two or more paws [3]. The affected areas are erythematous, with comedones, hair loss, follicular papules to pustules and scales. Lymphadenopathy is commonly associated with the disease and secondary bacterial infections are very frequent [5]. Although some young dogs with an early generalized form can self-cure naturally, it is impossible to clinically ascertain which animals will progress to the more severe state. The diagnosis is typically based on clinical signs and is confirmed by the presence of mites in deep skin scrapings. Although Demodex mites are part of the normal microfauna, it is uncommon to find the mites, even by performing several deep skin scrapings. If a mite is found, this should raise suspicion and additional skin scrapings should be performed. Finding more than one mite is strongly suggestive of clinical demodicosis [5, 9].


Despite recent advances with new acaricidal drugs, generalized demodicosis remains a very challenging disease to treat effectively. Amitraz, as a rinse or sponge -on, has been approved for the treatment of canine generalized demodicosis in many countries for decades. Several amitraz-based protocols have been described at various concentrations and frequencies. Efficacy data are reported to be variable, it is time-consuming, and there may be safety issues [11]. Protocols based on daily to weekly oral or subcutaneous injections of macrocyclic lactones including ivermectin, doramectin, and moxidectin have been published but represent off-label use with potential for toxicity, especially in dogs mutated for MDR-1 (P-glycoprotein deficiency), especially including colley breeds [9, 11]. Daily oral milbemycin oxime at a dose of 500 mg/kg is registered in many countries for the treatment of canine demodicosis [7].


Eighteen mongrel dogs (12 males, 6 females) weighing from 6 to 19 kg and being at least 1-year old were included. All had clinical signs of Demodex infestation such as erythema, hair loss, seborrhea, follicular casts, scales, and crust in at least five spots or on an entire body region. Deep skin scrapings performed at the time of inclusion confirmed an average count of 527 D. canis mites for five lesion sites per dog. Morphological observations of the mites clearly identified them as Demodex canis type. Except for clinical signs of demodicosis, dogs were otherwise declared in good general condition by a veterinarian at the time of enrolment. The health condition of the dogs was monitored daily from inclusion (Day -7) to study end (Day 84). Significant secondary bacterial infections were reasons for exclusion.


The Inclusion and Post-treatment mite counts within each group were compared using an ANOVA with time (pre- or post-treatment) and dog effects. A 5% level of significance for the within-group comparison (pre-treatment live mite counts vs post-treatment live mite counts) was used. The three groups were compared descriptively with respect to the percent reduction in mite counts. The success rate was defined as the percentage of dogs in each group that were negative for live mites at the time of scraping.


Both monthly and bi-weekly treatments with Certifect were regarded as effective in treating dogs with generalized demodicosis. Bi-weekly treatments did however result in a complete disappearance of mites in the scrapings at Day 84.


Advantage utilizes revolutionary new chemistry to produce unprecedented results on cats and dogs. Advantage contains imidacloprid, a chloronicotinyl nitroguanidine synthesized from the nitromethylene class of compounds. This new active ingredient has a mode of action unlike any other flea control product on the market.


Revolution (Selamectin) is a topical insecticide used for the treatment and prevention of fleas, ear mites, some internal parasites, and some types of mites and ticks; and the prevention of heartworm disease. Over 98% of fleas on the pet are killed within 36 hours of application. Once in contact with Revolution, fleas will not lay viable eggs. Selamectin kills parasites by blocking nerve signal transmissions. Revolution enters the bloodstream through the skin. It then stays in the bloodstream protecting against heartworm disease, passes into the gastrointestinal tract where it can kill certain intestinal parasites, and passes into the sebaceous glands and then onto the hair and skin providing protection against fleas and certain mites and ticks. Revolution is safe in dogs and cats from 6 weeks of age and can be used in breeding, pregnant and nursing dogs and is safe in collies.


Promeris (dogs) is a topical, waterproof spot on application for the control of fleas and ticks in dogs. It is applied once a month. Promeris contains metaflumizone and amitraz. Metaflumizoneis a neurotoxin; it blocks the movement of sodium required to propagate a nerve impulse along the neuron. This results in reductions in feeding, loss of coordination, paralysis and death of fleas. Amitraz is effective against ticks. Promeris is safe in dogs older than 8 weeks of age.


Pro-Ban, Miles is one commercially available product that contains an insecticide, cythioate, and is administered orally every three days. This product works by creating a toxic dose of organophosphate within the blood stream of the dog. This dose is enough to kill the flea when it feeds. This product does not prevent fleas from biting, and therefore, will not help a pet with flea allergies. Indications for this product might include a household where the humans are unable to provide other methods of treatment, such as shampoos, or where the humans are intolerant to powders, sprays, household products, etc. The oral product does not provide complete control of fleas, but is effective in reducing the numbers of fleas in a controlled environment. As with the organophosphate pour-on, other organophosphates should not be used in the environment or topically, since the risk of toxicosis would be increased. The pet should also be tested negative for heartworms.


Comfortis (Spinosad) is a monthly chewable oral medication for the treatment of flea allergic dermatitis. Spinosad is a derivative of macrolide antibiotics Spinosad attacks the nervous system of the flea acting on the nicotinic acetylcholine receptors, there is no interaction with other insecticides. The fleas are paralyzed and start to die with 30 minutes of administering the tablet and is 100% effective within 4 hours. The fleas are killed before they have time to lay eggs. In severe environmental contamination fleas may persist for some time due to fleas emerging from existing pupae. Safe for use in dogs over 14 weeks of age. 041b061a72


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